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The naked mole rat (NMR) demonstratesan unusual phenotype of significantly delayed aging andthe longest lifespan of any rodent (about 30 years) fi ve timesthe expected lifespan based on body size, and exceptionalcancer resistance, despite elevated markers for OS and shorttelomeres (Buffenstein et al., 2011).

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If chronic meningitis remainsuntreated, late neurologic complications can include sei-zures, focal neurologic deficits due to arteritis and infarc-tion (M. Long-term studies are more likely to be contaminated by historyeffects than are studies in which data are collected over a short time. A simple metric for such cases is the AUC inthe tissue, which is defined mathematically as the integralof the concentration over time

A simple metric for such cases is the AUC inthe tissue, which is defined mathematically as the integralof the concentration over time.

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True breastsdevelop along the thoracic ridge; the other breasts along themilk line atrophy. This is also iatrogenicallyinduced in procedures such as thoracoscopy or a thoracotomy (see Chapter 4, “Thora-cotomy” section)

This is also iatrogenicallyinduced in procedures such as thoracoscopy or a thoracotomy (see Chapter 4, “Thora-cotomy” section). SIRT3 reduces OS by increasing activityof SOD2 through deacetylation (Tao et al., 2010; Qiu et al.,2010)

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Renal andhepatic damage may occur following prolonged exposure.While 1,4-dioxane is considered “likely to be carcinogenicto humans” based on animal data via oral exposure, humanstudies are inconclusive.

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